Comparison of three methods for determination of glomerular filtration rate in chronic glomerulonephritis patients
10.3760/cma.j.issn.1001-7097.2010.10.009
- VernacularTitle:测定慢性肾小球肾炎患者肾小球滤过率的三种方法比较
- Author:
Peng XIE
;
Weijie WU
;
Jianmin HUANG
;
Liping PAN
;
Dongxue LI
;
Fang ZHANG
;
Peng FU
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis,chronic;
Glomerular filtration rate;
Renal dynamic imaging;
Dual plasma sample method;
Plasma clearance of creatinine method
- From:
Chinese Journal of Nephrology
2010;26(10):766-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the accurate measurement of glomerular filtration rate (GFR) in chronic glomerulonephritis (CGN)patients. Methods Forty-two patients were enrolled in the study, including 15 females with age from 18 to 73 years old (mean 46 years old) and 27 males with age from 20 to 77 years old (mean 48 years old). The methods used for measuring GFR were classical dual plasma sample clearance method (tGFR), considered to be the gold standard,renal dynamic imaging method (dGFR), 24-hour creatinine clearance method (24hCcr). The difference and correlation amony them were analyzed. When the difference was significant, Pearson correlation and linear regression analysis were further performed. The difference of GFR detected by dGFR between left and right kidney of patients was compared simultaneously. A two-sided P value＜0.05 was considered as statistically significant. Results Either dGFR or 24hCcr was statistically different from tGFR, but had excellent correlation with tGFR, and the coefficient was 0.916 (P=0.000) and 0.957 (P=0.000) respectively. The linear regressions correlation existed and the regression equations were tGFR=0.936 dGFR-4.648 (F=208.941, P=0.000), tGFR =0.887 24hCcr+2.919 (F=376.513, P=0.000) respectively. Difference had not statistically significance between left and right kidney of patients (P=0.591). Conclusions Neither dGFR nor 24hCcr can substitute tGFR, but both can reflect the GFR of the CGN patients safely and effectively. The decrease of GFR is homochronous for left and right kidney of CGN patients. Therefore, the 24hCcr can be chosen to evaluate the GFR in the hospitals without SPECT.
