Research advances of CD+4CD+25 Treg cell and it's function in GVHD
10.3760/cma.j.issn.1006-9801.2010.10.029
- VernacularTitle:CD+4CD+25调节T细胞的生物学功能及其在移植物抗宿主病中作用的研究进展
- Author:
Ruirui REN
;
Yanyan NIU
;
Liangming MA
- Publication Type:Journal Article
- Keywords:
Graft-versus-host disease;
CD+4 CD+25 regulatory T cells;
Allo-HSCT
- From:
Cancer Research and Clinic
2010;22(10):718-720
- CountryChina
- Language:Chinese
-
Abstract:
CD+4 CD+25 regulatory T cell (Treg) has immune incompetent and immune suppression functions, and is a kind of suppressor T-cell subsets. It can inhibit the activation and proliferation of CD+4 T cells and CD+8 T cells, so as to effectively suppress the immune system to foreign organ and reduce the graftversus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT), without affecting the role of graft-versus-leukemia (GVL), which plays an important role in the transplantation immune tolerance.
