Correlative analysis between contrast-enhanced ultrasonography and 99mTc-DTPA renography in evaluation of renal insufficiency
10.3760/cma.j.issn.1001-7097.2010.07.007
- VernacularTitle:超声造影定量技术与核医学肾图评价肾功能不全的相关研究
- Author:
Yi DONG
;
Wenping WANG
;
Jiaying CAO
;
Peili FAN
;
Xiyuan LIN
;
Pengcheng HU
- Publication Type:Journal Article
- Keywords:
Kidney insufficiency,chronic;
Ultrasonography;
Glomerular filtration rate;
99mTc-DTPA renography
- From:
Chinese Journal of Nephrology
2010;26(7):516-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the contrast-enhanced ultrasonography (CEUS) in quantitative diagnosis of chronic renal insufficiency. Methods Correlation of CEUS indexes with glomerular filtration rate (GFR) detected by 99mTc-DTPA renography was examined. Thirty-three cases of clinical chronic renal insufficiency were enrolled in the study. They were 15 males and 18 females with average age of (43.33±6.78) years. After intravenous bolus injection of 1 ml SonoVue,CEUS of renal cortex blood perfusion was performed successfully, and a time-intensity curve (TIC)was created with PHILIPS iU22 system's QLAB software. A 148 to 222 MBq dose of 99mTc-DTPA was injected as a bolus from antecubital vein. Renal scintigraphic images were collected immediately and GFR was obtained. Results The significant correlation coefficients between GFR and CEUS quantitative indexes were as follows: rAUC (area under curve)=0.886 (P＜0.05), rA (slope rate of ascending curve, A) =0.804(P＜0.05). However, rDPI (derived peak intensity, DPI)=0.021 (P＞0.05), rTTP (time to peak, TTP) =0.043 (P＞0.05), rα (slope rate of descending curve,α)=0.039 (P＞0.05). Conclusion CEUS can precisely display the hemodynamic change of chronic renal insufficiency, which is well correlated with GFR by 99mTc-DTPA renography.
