Expression and significance of Ki-67 antigen in bladder cancer
10.3760/cma.j.issn.1006-9801.2009.11.010
- VernacularTitle:Ki-67抗原在膀胱癌中的表达及其意义
- Author:
Wei CHENG
;
Jingyu WANG
;
Dongwen WANG
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Immunohistochemistry;
Ki-67 antigen
- From:
Cancer Research and Clinic
2009;21(11):748-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Ki-67 in bladder transitional cell carcinoma and its relationship with grade and stage. Methods Immunohistochemistry method were used to detect the expression of Ki-67 in bladder transitional cell carcinoma and control groups. Results The positive expression rate of Ki-67 antigen in 60 cases of bladder cancer, 20 cases of benign bladder disease and 10 cases normal bladder mucosa were 25.9 %, 10.3 % and 1.1 %. There were significantly difference among each group. The more grade and stage, the greater expression of Ki-67 antigen. Conclusion Ki-67 antigen is related to cell proliferation. The expression of the Ki-67 antigen in bladder cancer is closely related to the grade extent of tumor, and it is an important cell proliferation indicator. As a signal, Ki-67 antigen reflects cell proliferation, measurement of the expression of the Ki-67 antigen could reflect the condition of tumor cell proliferation. It might be an important prognostic factor for judging the occurrence, development and prognosis of the tumor.