Expression and significance of Ki-67 antigen in bladder cancer

VernacularTitle:Ki-67抗原在膀胱癌中的表达及其意义
Author: Wei CHENG ; Jingyu WANG ; Dongwen WANG
Publication Type:Journal Article
Keywords: Urinary bladder neoplasms; Immunohistochemistry; Ki-67 antigen
From: Cancer Research and Clinic 2009;21(11):748-749
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of Ki-67 in bladder transitional cell carcinoma and its relationship with grade and stage. Methods Immunohistochemistry method were used to detect the expression of Ki-67 in bladder transitional cell carcinoma and control groups. Results The positive expression rate of Ki-67 antigen in 60 cases of bladder cancer, 20 cases of benign bladder disease and 10 cases normal bladder mucosa were 25.9 %, 10.3 % and 1.1 %. There were significantly difference among each group. The more grade and stage, the greater expression of Ki-67 antigen. Conclusion Ki-67 antigen is related to cell proliferation. The expression of the Ki-67 antigen in bladder cancer is closely related to the grade extent of tumor, and it is an important cell proliferation indicator. As a signal, Ki-67 antigen reflects cell proliferation, measurement of the expression of the Ki-67 antigen could reflect the condition of tumor cell proliferation. It might be an important prognostic factor for judging the occurrence, development and prognosis of the tumor.