Effects of aerobic exercise on plasma tissue plasminogen activator/plasminogen activator inhibitor-1 and postaglandin I2/thromboxanes A2 in rats fed a high methionine diet
10.3760/cma.j.issn.0254-1424.2010.11.006
- VernacularTitle:有氧运动训练对高蛋氨酸饮食大鼠血浆组织纤溶酶原激活物/纤维蛋白溶酶原激活因子抑制物-1和前列腺素I2/血栓烷A2系统的影响
- Author:
Xiaoli REN
;
Bo YANG
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Hyperhomocysteinemia;
Prostaglandin;
Thromboxane;
Fibrinolysis;
Aerobic exercise
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2010;32(11):822-825
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of aerobic training on plasma tissue plasminogen activator/plasminogen activator inhibitor-1 and postaglandin I2/thromboxanes A2 in rats fed a high methionine diet. Methods Ninetysix male Wistar rats were randomly divided into a normal diet control group (CR), a high methionine diet group (MR)and a high methionine diet plus 90 min aerobic training intervention group (T + MR). After 8 weeks of training, the plasma level of homocysteine (Hcy) 6-keto-PGF1α, TXB2, t-PA and PAI-1 were measured. Results Plasma Hcy in the MR group increased two-fold as compared with the CR group, whereas t-PA/PAI-1 and 6-keto-PGF1α/TXB2 of the MR group decreased significantly. Plasma Hcy in the T + MR group significantly decreased, while plasma t-PA/PAI-1 and 6-ketoPGF1α/TXB2 increased significantly compared with the MR group. The above parameters were not different in the T + MR group from those of the CR group. Conclusions Hyperhomocysteinemia could be induced by a high methionine diet.Proper training can decrease the plasma Hcy level of rats fed with a high methionine diet, and correcting the imbalance of t-PA/PAI-1 and 6-Keto-PGF1α/TXB2 could prevent the development of hyperhomocysteinemia.
