Association of complement C1q gene polymorphism with the susceptibility to lupus nephritis in the people of Wuhan district, Hubei province, China
10.3760/cma.j.issn.1001-7097.2009.12.007
- VernacularTitle:补体C1q基因调节区多态性与武汉地区人群狼疮肾炎易感性的关系
- Author:
Ling FU
;
Jianhua PAN
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Complement C1q;
Polymorphism;
single nucleotide
- From:
Chinese Journal of Nephrology
2009;25(12):912-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of complement C1q polymorphism with the susceptibility to lupus nephritis (LN) in the people of Wuhan district,Hubei province, China. Methods The polymorphie frequency at C1q region of accommodation Aexon2, Bexonl,Bexon2,Cexon2 in 30 LN patients,20 non-LN nephropathy controls and 10 healthy controls were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)and then the sequence of mutational site was detected directly.Association of C1q polymorphism with LN was analyzed by chi-square criterion. Results Already repoaed mutable points oversea,such as C1qAexon2:C→T,C1qBexon1:G→A,C1qBexon2:G→A,C1q Cexon2:C deletion,in C1q region of accommodation were not detected in 30 LN patients,20 nonLN nephropathy controls and 10 healthy controls. Conclusion Polymorphism in the regulatory region of C1q region of accommodation is not associated with the susceptibility to LN in the people of Wuhan district,Hubei province,China,which may be influenced by a small number of subjects.
