Association of HLA-A * 3101, B * 4001, B * 5801 and DRB1 * 1602 alleles with hemorrhagic fever with renal syndrome disease in Han population of Zunyi province
10.3760/cma.j.issn.0254-5101.2010.11.008
- VernacularTitle:HLA-A*3101、B*4001、B*5801、DRB1*1602等位基因与遵义地区汉族肾综合征出血热发病的相关性研究
- Author:
Nalin QIN
;
Huiqin LAN
;
Lin XU
;
Xianying TANG
;
Wanbang SUN
;
Xinsheng YAO
;
Junmin LUO
- Publication Type:Journal Article
- Keywords:
Human leukocyte antigen;
Gene haplotype;
Hemorrhagic fever with renal syndrome;
Association
- From:
Chinese Journal of Microbiology and Immunology
2010;30(11):1004-1007
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between HLA-A*31, B*40, B*58 and DRB1*16 allele polymorphisms and onset of hemorrhagic fever with renal syndrome (HFRS) in Zunyi Han population. Methods Using group study, HLA-A*31, B*40, B*58 and DRB1*16 genotyping was conducted in 100 HFRS cases and 100 controls among Han population in Zunyi area with polymerase chain reactionsequence specific primer(PCR-SSP), gene frequency (GF) and relative risk (RR) were calculated and compared. Results The results showed that the frequencies of A*3101, B*5801 and DRB1*1602 were increased in patients as compared to the healthy controls ( RR = 13. 825, x2 = 4. 296, P = 0. 038; RR =2.614,x2 =6. 133,P=0.013;RR =8.523,x2 =8. 865,P=0. 003). The frequency of B*4001 in patients with HFRS were significantly lower than that in the healthy controls( RR =0.414,x2 =6.640,P =0. 010).Conclusion These results suggest that HLA-A*3101, B*5801 and DRB1*1602 haplotypes were strongly associated with susceptibility to HFRS disease in Zunyi Han population and allele HLA-B*4001 might be associated with protection against hantaviruses infection.
