Prognostic factors for the survival of patients with thoracic esophageal squamous cell carcinoma: the importance of tumor length and lymph node status
10.3760/cma.j.issn.1006-9801.2010.11.010
- VernacularTitle:胸段食管鳞状细胞癌淋巴结转移、肿瘤长度与预后的关系
- Author:
Shuangping ZHANG
;
Chunli WANG
;
Yun CHEN
;
Wei GUO
;
Yanyan MA
;
Xiaoyou HAN
;
Shoushan FENG
;
Guoping TONG
;
Zhiheng YOU
;
Xiaojun WANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Surgical procedures,oporative;
Lymphatic metastasis;
Prognosis;
Tumor length
- From:
Cancer Research and Clinic
2010;22(11):748-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of tumor length and number of positive lymph nodes and the ratio of positive lymph nodes on survival in patients with esophageal squamous cell carcinoma.Methods From July 1995 to July 2005, a total of 6,691 resected lymph nodes were obtained from 526patients who underwent curative resection of the primary tumour with systematic lymphadenectomy. The survivals were analysed by life tables and Kaplan-Meier methods. Results Among patients with regional disease, the number of positive lymph nodes (＞3) was related to an increasing risk. The proportion of positive lymph nodes compared with the number of lymph nodes dissected (20 %) conferred an increased risk. The tumor length (≤5 cm, 5 cm ＜ length ＜ 7 cm, ＞7 cm) was related to an increasing risk (84.74 %, 47.79 %,36.90 %, 35.52 %; 73.41%, 46.29 %, 23.87 %, 20.64 %; 64.44 %, 13.92 %, 0, 0). Conclusion Tumor length,the number of positive lymph nodes, and the ratio of positive lymph nodes are important prognostic factors for survival in patients with esophageal carcinoma. The PTNM classification system for patients with esophageal carcinoma might consider adding number of positive lymph nodes as an important prognostic factor.
