Expression and significance of MIF protein in vascular endothelial cell in esophageal squamous cell carcinoma tissue

VernacularTitle:食管鳞状细胞癌组织微血管内皮细胞中巨噬细胞移动抑制因子蛋白的表达及其意义
Author: Jinsong ZHAO ; Yulan GUO ; Kelong LIAO ; Kang YANG
Publication Type:Journal Article
Keywords: Macrophage migration-inhibitory factors; Esophageal neoplasms; Microvessel density
From: Cancer Research and Clinic 2010;22(11):752-754
CountryChina
Language:Chinese
Abstract: Objective To detect the microvessel density(MVD) marked by MIF protein in esophagus squamous cell carcinoma(ESCC), and to see if a relationship exists between microvessel density(MVD) and clinicopathologic features. Methods The expression of MIF in vascular endothelial cell in forty ESCC specimens was examined by immunohistocbemistry staining, calculated the mean of MVD and analysed the relationship with clinicopathologic features. Results The positive rate of MIF protein was 95.00 %(38/40) in ESCC vascular endothelial cell. Compared with the normal esophageal squamous tissue[32.50 %(13/40)], there was significant difference in statistics, the mean of MVD was 26.5±8.5. MVD was positively correlated with the tumor TNM stages and lymph node motastasis. Conclusion MIF can be used in tagging vascular endothelial cell, MVD of ESCC was positively correlated with the tumor TNM stages and lymph node metastasis. It might be an major prognostic factor in ESCC.