Detection and its clinical significance of CD+4 CDHi25 CDLo127 regulatory T cells in peripheral blood of patients with thyroid neoplasm
10.3760/cma.j.issn.1006-9801.2010.12.009
- VernacularTitle:甲状腺肿瘤患者外周血CD+4CDHi25CDLo127调节性T细胞的检测及其临床意义
- Author:
Yutian CUI
;
Yanfeng WANG
;
Yi DING
;
Wen SU
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Goiter,nodular;
T-lymphocytes,regulatory
- From:
Cancer Research and Clinic
2010;22(12):822-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze CD+4 CDHi25 CDLo127 regulatory T cells (Treg) in peripheral blood of patients with thyroid nodules and differentiated thyroid cancer and their change regularity, and to investigate the immunosuppression mechanism. Methods The peripheral blood was collected from 175 patients with thyroid nodules, including 43 patients with differentiated thyroid cancer and 132 patients with nodular goiter.By using monoclonal antibodies, the blood samples were evaluated with the flow cytomertry for lymphocyte subsets and Treg cells. Results The results showed the prevalence of the CD+4 CDHi25 CDLo127 Treg in differentiated thyroid cancer group [(6.48±1.49) %] and nodular goiter group [(6.23+1.67) %] was higher than those in the healthy group [(5.62±1.48) %], and the difference was significant(P < 0.005), but there was no significant difference between the nodular goiter group and differentiated thyroid cancer group (P >0.005).Conclusion It is concluded that the relative increase of CD+4 CDHi25 CDLo127 Treg in peripheral blood of patients with nodular goiter and differentiated thyroid cancer may be related to immunosuppression and tumor progression.
