Expression and relationship between matrix metalloproteinase-7 and E-cadherin in gastric cancer

VernacularTitle:基质金属蛋白酶-7和E-钙黏附素在胃癌组织中的表达及其相关性
Author: Rongkun DONG ; Du ZHANG ; Jianpeng HUANG ; Mingfu HAN ; Qibin WANG ; Jun FU ; Lin WANG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Matrix metalloproteinase 7; E-cadherin; Neoplasm invasiveness; Neoplasm metastasis
From: Cancer Research and Clinic 2011;23(1):25-27
CountryChina
Language:Chinese
Abstract: Objective To evaluate the expressions of MMP-7, E-cadherin in gastric carcinoma, and their relationship with tumor cell invasion and metastasis. Methods The MMP-7 mRNA and E-CD mRNA were detected by hybridization in situ in 78 gastric cancer tissues. Then analyze the relationship between the expression of MMP-7, E-CD and clinicopathological features. Results The expressions of MMP-7 and Ecadherin were significantly related with the invasion and metastasis of gastric cancer cell. The E-CD mRNA expression rate in MMP-7 mRNA positive gastric carcinoma tissue was much lower than that in negative carcinoma tissue (9.09 % vs 66.70 %). Conclusion Expression of MMP-7 mRNA and E-CD mRNA is associated with invasion, metastasis. Detection of MMP-7 mRNA and E-CD mRNA in bioptic specimens may be helpful in predicting tumor metastatic and recurrent potential and prognosis for patients with gastric carcinoma.