Expression and clinical significance of C-erbB-2 in colorectal carcinoma
10.3760/cma.j.issn.1006-9801.2011.01.010
- VernacularTitle:C-erbB-2在结直肠癌中的表达及其临床意义
- Author:
Qingguo LI
;
Changjian WANG
;
Shiyan YAN
;
Enyi SHI
;
Hongfen LU
;
Guangfa ZHAO
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Genes,erbB-2;
Immunohistochemistry
- From:
Cancer Research and Clinic
2011;23(1):31-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of oncogene C-erbB-2 and its significance in colorectal carcinoma. Methods Immunohistological EnVision staining was used to detect the expression of C-erbB-2 in 171 colorectal carcinoma, and 15 normal colorectal tissues were taken as controls. Results The positive percentages of C-erbB-2 in colorectal carcinoma and normal colorectal tissues were 23.4 % (40/171)and 0, which was significantly different (P <0.05). Only 5 samples showed strong positive expression (++ and +++) on epicyte, no relationship was found between C-erbB-2 expression and patients' gender, tumor differentiation, tumor stage, vascular and lymph node involvement, etc(P >0.05). The five year survival rate were 69.5 % (91/131) and 65.0 % (26/40) of C-erbB-2 negative and positive expression, the difference was not statistical (P >0.05). Conclusion There was on significant association between C-erbB-2 expression and clinicopathologic characteristics of colorectal carcinoma. C-erbB-2 did not present prognostic value in colorectal carcinoma.