Expression and clinical significance of C-erbB-2 in colorectal carcinoma

VernacularTitle:C-erbB-2在结直肠癌中的表达及其临床意义
Author: Qingguo LI ; Changjian WANG ; Shiyan YAN ; Enyi SHI ; Hongfen LU ; Guangfa ZHAO
Publication Type:Journal Article
Keywords: Colorectal neoplasms; Genes,erbB-2; Immunohistochemistry
From: Cancer Research and Clinic 2011;23(1):31-33
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of oncogene C-erbB-2 and its significance in colorectal carcinoma. Methods Immunohistological EnVision staining was used to detect the expression of C-erbB-2 in 171 colorectal carcinoma, and 15 normal colorectal tissues were taken as controls. Results The positive percentages of C-erbB-2 in colorectal carcinoma and normal colorectal tissues were 23.4 % (40/171)and 0, which was significantly different (P ＜0.05). Only 5 samples showed strong positive expression (++ and +++) on epicyte, no relationship was found between C-erbB-2 expression and patients' gender, tumor differentiation, tumor stage, vascular and lymph node involvement, etc(P ＞0.05). The five year survival rate were 69.5 % (91/131) and 65.0 % (26/40) of C-erbB-2 negative and positive expression, the difference was not statistical (P ＞0.05). Conclusion There was on significant association between C-erbB-2 expression and clinicopathologic characteristics of colorectal carcinoma. C-erbB-2 did not present prognostic value in colorectal carcinoma.