Expression and significance of Skp2 and Cx43 in cervical carcinoma

VernacularTitle:S期激酶相关蛋白2与间隙连接蛋白43在子宫颈癌中的表达及其意义
Author: Zhen LIANG ; Lixin SUN ; Hongwei ZHAO
Publication Type:Journal Article
Keywords: Uterine cervical neoplasms; S-phase kinase-associated proteins; Connexin 43
From: Cancer Research and Clinic 2010;22(12):840-842
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of Skp2 and Cx43 in cervical carcinoma and to study their relationships and clinical significance. Methods The expression of Skp2 and Cx43 was examined by immunohistochemical method in 48 cases of cervical carcinoma tissue, 84 cases of cervical intraepithelial neoplasia (CINⅠ - Ⅱ 45 cases, CINⅢ 39 cases), 28 cases of chronic cervicitis. Results Skp2 expression in cervical carcinoma was higher than that in the CINⅠ - Ⅱ and chronic cervicitis (P <0.05), Cx43 expression was lower in cervical carcinoma than that in the CINⅢ, CINⅠ - Ⅱ and chronic cervicitis (P <0.05). The expression of Skp2 was correlated with histological differentiation and lymph node metastasis (P <0.05). The expression of Cx43 was correlated with the lymph node metastasis (P <0.05). Besides, the expression of Skp2had a negative correlation with that of Cx43. Conclusion Skp2 and Cx43 may play an important role in the genesis and development of cervical carcinoma.