Expression and clinical significance of Her-2/neu and Topo Ⅱ α protein in gastric cancer
10.3760/cma.j.issn.1006-9801.2011.01.024
- VernacularTitle:Her-2/neu、TopoⅡα蛋白在胃癌中的表达及其临床意义
- Author:
Hua WU
;
Zhao MA
;
Wenping LIU
;
Wenjuan LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Genes,erbB-2;
Genes,neu;
DNA topoisomerases,type Ⅱ
- From:
Cancer Research and Clinic
2011;23(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Protocarcinogenic gene Her-2/neu was closely related to the development of gastric cancer. Herceptin is an antibody according to Her-2/neu and is used for treating breast cancer. Topo Ⅱ α is the important Nuclear enzymes needed by DNA duplicate, and is closely related to the proliferation of malignant tumors, so it is the important target enzymes of cancer chemotherapy. Her-2/neu and Topo Ⅱ α are located in the same chromosomes, there are correlation between the two genes' proliferation or loss. We reviewed the expression of Her-2/neu and Topo Ⅱ α in the stomach and the new progress of the correlation between the two genes home and abroad in this paper, which provides new methods for the prevention and treatment of gastric cancer.
