Application of ATP-TCA in chemotherapy of human cardia cancer

VernacularTitle:三磷酸腺苷生物荧光体外药物敏感检测法在贲门癌化疗中的应用
Author: Lei WANG ; Chunli WANG ; Shuangping ZHANG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Fluorescent antibody technique; Drug therapy,combination; Microbial sensitivity test
From: Cancer Research and Clinic 2010;22(12):825-827
CountryChina
Language:Chinese
Abstract: Objective To investigate the drug sensitivity of cardia tumors in vitro by ATP-TCA, and to provide basis of clinic chemotherapy. Methods 42 cardia tumors were tested by ATP-TCA to determine and assess the drug sensitivity of 8 common chemotherapeutics. Correlation analysis was done between the clinical classification and the drug sensitivity. Results The drug sensitivity had significant difference among cardia tumors. From high to low, it was ADM>MMC>PTX> 5-Fu>HCT =VP16>CDDP>IFO, Sensitive degree were 50.00 %, 35.45 %, 31.25 %, 23.53 %, 10.53 %, 10.53 %, 7.69 %, 5 %. Sensitivity of the same drug in different pathologic stages had no significant difference. Conclusion ATP-TCA can play a guiding role in individual chemotherapy for human cardia cancer.