Change of the methylated sFRP gene and the progress in colorectal cancer
10.3760/cma.j.issn.1006-9801.2010.12.027
- VernacularTitle:分泌型卷曲相关蛋白基因甲基化与大肠癌的研究进展
- Author:
Yongkun LI
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
DNA methylation;
Biological markers
- From:
Cancer Research and Clinic
2010;22(12):862-864
- CountryChina
- Language:Chinese
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Abstract:
With the development of epigenetics, more and more studies have confirmed that DNA methylation is closely related with the tumorigenesis. Secreted frizzled-related protein (sFRP) gene methylation can result in the silence of gene expression, decrease in the inhibition of the Wnt signal pathway and promoting the occurrence and progress of tumor, especially in the colorectal cancer. When the function of sFRP recover, the activity of Wnt signal pathway is inhibited, thereby inhibiting formation and progress of tumor and promoting apoptosis of tumor cell. sFRP gene family methylation is closely related with the occurrence and progress of colorectal cancer. Therefore, the detection of SFRPs methy]ation is expected to be a new way for colorectal cancer early screening.
