Association of killer cell immunoglobin-like receptor gene with bone marrow failure syndromes
10.3760/cma.j.issn.0254-5101.2011.01.019
- VernacularTitle:杀伤细胞免疫球蛋白样受体基因与骨髓衰竭性疾病的相关性研究
- Author:
Yun WANG
;
Xiangshan CAO
;
Qiang WU
- Publication Type:Journal Article
- Keywords:
Killer cell immunoglobin-like receptor;
Polymorphism;
Bone marrow failure syndromes
- From:
Chinese Journal of Microbiology and Immunology
2011;31(1):69-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of killer immunoglobulin-like receptors(KIR)gene polymorphism with bone marrow failure syndromes(BMFS). Methods SSP-PCR was used to examine the genotypic makeup of KIR in patients with aplastic anemia( AA), myelodysplatic syndrome (MDS) and healthy controls in our department. Results All the 16 KIR genes which had been prescribed were identified. The frequencies of KIR-2DS1, 2DS2, 2DS3, 2DS5 and 3DS1 genes were showed increased in patients with AA, MDS than in healthy controls. The patients with AA had lower frequency of KIR-2DS5 than the patients with MDS. Conclusion The increased frequencies of these activated KiRs in patients with MDS and AA suggest that the abnormal immunogenetic might be related to the pathogenesis of BMFS.
