Effects of laser, radiofrequency and intensive pulse light on injectable polymethylmethacrylate ( Artecoll)
10.3760/cma.j.issn.1671-0290.2011.01.013
- VernacularTitle:激光等物理治疗对置入的聚甲基丙烯酸甲酯微球结构影响的观察
- Author:
Ye FEI
;
Xiangdong CHEN
;
Beiqing WANG
;
Jingan CHEN
;
Zhengyu SHEN
;
Hui XU
;
Jianhang LIU
;
Zhen ZHANG
- Publication Type:Journal Article
- Keywords:
Polymethylmethacrylate;
Injectable dermal filler;
Laser;
Radiofrequency;
Intensive pulse light
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2011;17(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of polymethylmethacrylate/PMMA (Artecoll) as an injectable dermal filler after using laser, radiofrequency and intensive pulse light. Methods In vitro, factional photothermolysis (Affirm) was directly used on the PMMA to see if there was any change in the structure or surface smoothness. In vivo, pig and guinea pig were used as the short-term and long-term models, respectively, for Artecoll. The dermal filler was first injected and then laser treatments conducted.The skin sample was observed through light microscope, scanning electronic microscope and transmission electronic microscope to see whether there were any structural changes, infiltration of inflammatory cells and the regeneration of collagen. Results Through the microscopic observation of in vitro experiment and the animal models, no distortion or rupture of the microsphere were found after the laser treatment. No uneven surface was found in the PMMA microsphere either. The microshpere was surrounded by the inflammatory cells. The infiltration was mild to intermediate with few foreign body giant cells even after several treatments of laser. There was no macrophage seen. But the collagen regeneration was distinguishable after the laser treatment. No obvious structural change was found eventually. Conclusion Artecoll is a safe and effective permanent injectable dermal filler for wrinkle reduction and contour refining.
