Apolipoprotein E genotype polymorphism and cerebral palsy in children
10.3760/cma.j.issn.0254-1424.2011.01.013
- VernacularTitle:载脂蛋白E基因多态性与脑性瘫痪相关性的初步研究
- Author:
Xiaojie LI
;
Liping WANG
;
Qifeng SUN
- Publication Type:Journal Article
- Keywords:
Cerebral palsy;
Apolipoprotein E;
Genotypes
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2011;33(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between apolipoprotein E (apoE) genotype polymorphism and cerebral palsy (CP) in Han Chinese children. Methods Two hundred and forty Han Chinese children were selected, including 120 children with cerebral palsy (CP group) and 120 normal children (control group).Polymerase chain reaction-restricted fragment length polymorphism analysis was used to determine the genotype and alleles of apoE genotype in the two groups. Results The genotype distributions of apoE in the two groups were consistent with the existence of a Hardy-Weinberg equilibrium. There were significant differences in the distributions of allelic frequency and apoE genotype between the two groups. Carrying the ε4 allele was related to cerebral palsy, and the overall risk for cerebral palsy was elevated about 5.5-fold among children carrying the ε4 allele.Conclusions There is an association between apoE genotype and cerebral palsy, and apoE's ε4 allele is the associated risk factor.
