Low-intensity anticoagulation therapy in the pregnant women with mechanical heart valves:a report with 56 cases
10.3760/cma.j.issn.1001-4497.2011.01.004
- VernacularTitle:心脏机械瓣膜置换术后妊娠妇女低强度华法林抗凝治疗56例
- Author:
Li DONG
;
Xinhui LIU
;
Yingkang SHI
;
Eryong ZHANG
;
Xijun XIAO
;
Dan LIU
;
Xiao TENG
;
Li REN
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis implantation;
Pregnancy;
Warfarin;
Anticoagulation therapy
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2011;27(1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the method of low-intensity anticoagulation therapy in the pregnant women who had received mechanical heart valve replacemant, and the effects of warfarin on the pregnant women and their fetus. Methods This retrospective study involved 56 pregnant women( 61 pregnancies)who had received mechanical heart valve replacement.Their pregnant status, delivery, and anticoagulation therapy were observed and followed-up between May 1986 and November 2009 at West China Hospital of Sichuan University. Results All patients took oral anticoagulant (warfarin) throughout pregnancy. The dose of domestic warfarin was ( 3.02 ± 0.85 ) mg/d ( in 42 cases), and the dose of imported warfarin was (2.84 ± 0.57 )mg/d (in 14 cases). The mean INR value of 401 samples from patients was 1.67 ±0.58. No thromboembolism or major hemorrhagic complications occurred. Minor bleeding occurred in 11 pregnancies. Forty-seven patients had term delivery, 7 had premature birth, 6 had spontaneous abortion, and 1 had intrauterine fetal death. Six newborns were born with low birth weight (2.3 ± 0. 5 ) kg, and no abnormal fetus was observed. Conclusion The low-intensity anticoagulation therapy with warfarin (at a dose of less than 5 mg/d) and a INR target of 1.5 to 2.0 was safe and convenient for the pregnant women,who had received mechanical heart valve replacement. The abnormalities rate of fetus was low.
