The effect and their mechanism of acid pocket in reflux esophagitis
10.3760/cma.j.issn.0254-1432.2010.011.005
- VernacularTitle:酸袋在反流性食管炎中作用的研究
- Author:
Yedong HU
;
Lu BAI
;
Fei LIU
;
Wen XU
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Acid pocket;
Gastroesophageal reflux disease;
Reflux esophagitis
- From:
Chinese Journal of Digestion
2010;30(12):881-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the function of acid pocket in reflux esophagitis. Methods The 15 healthy controls and 24 reflux esophagitis patients were identified by reflux disease questionnaire (RDQ) and gastric endoscopy. The location of subjects' lower esophageal sphincter (LES) was determined by 4 channel esophageal manometry system. Then a single-channel pH electrode was positioned 1 cm below the distal border of the LES to monitor fasting pH for half an hour. After a standard meal, the pH was continuously measured for two hours. Then the electrode was moved to 5 cm above the proximal border of the LES to monitor the dynamic pH for 24 h.Results Acid pocket was found in 16 cases of reflux esophagitis patients(66.67%) and 10 cases of healthy individuals (10/15). Acid pocket occurred earlier in reflux esophagitis group than healthy controls [11.00(4.25-17.00) min vs 30.00(15.50-54.25) min, P＜0.05], and the average pH value was lower [1.84(1.59-2. 19) vs 2.32 (1.96-2.71), P＜0.05]. There was no statistic difference in mean pH value of gastroesophageal junction and the duration of acid pocket before the meal.Conclusion There is abnormal acid reflux in reflux esophagitis patients, and acid pocket with earlier occurrence and lower pH value may relevant to esophageal mucosal impairment.
