Preventive effect of rectal nonsteroidal anti-inflammatory drugs for post-ERCP pancreatitis

VernacularTitle:直肠非甾体类抗炎药对ERCP术后胰腺炎的预防作用
Author: Tingsong XIA ; Pengfei LIU
Publication Type:Journal Article
Keywords: Pancreatitis; Rectum; Endoscopic retrograde cholangiopancreatography; NSAIDs
From: Chinese Journal of Digestive Endoscopy 2010;27(6):301-302
CountryChina
Language:Chinese
Abstract: Objective To investigate the preventive and therapeutic effects of nonsteroidal anti-inflammatory drugs ( NSAIDs) via rectum for hyperamylasemia and pancreatitis after ERCP (endoscopic retrograde cholangiopancreatography).Methods Sixty patients who underwent ERCP for various reasons were randomly divided into preventive and control groups.In addition to routine diazepam (10 mg) and anisodamine (10 mg) given intramuscularly in both groups before ERCP, 100 mg of indometacin suppositories was administered by rectum in preventive group.Serum amylase level was measured before and 6 hours and 24 hours after the procedure.Results Serum amylase levels at 6 hours after ERCP in preventive and control groups were (367.5 ± 268.7 ) U/L and (1034.2 ± 713.5 ) U/L, respectively ( P < 0.05 ), which were (324.9±142.3)U/L and (826.8 ±395.7)U/L, respectively, at 24 hours after ERCP (P<0.05).Conclusion Rectal use of NSAIDs can prevent hyperamylasemia and acute pancreatitis induced by ERCP.