Clinical observation on proton pump inhibitor for treatment of gastroesophageal reflux symptom in continuous ambulatory peritoneal dialysis patients
10.3760/cma.j.issn.0254-1432.2009.07.007
- VernacularTitle:质子泵抑制剂治疗持续不卧床腹膜透析患者胃食管反流症状的疗效观察
- Author:
Rui DONG
;
Zhiyong GUO
;
Xueli LAI
;
Haiyan XU
;
Lili CAI
- Publication Type:Journal Article
- Keywords:
Gastroesophageal reflux;
Kidney failure,chronic;
Peritoneal dialysis,continuons ambulatory;
Proton pump inhibitora
- From:
Chinese Journal of Digestion
2009;29(7):459-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the gastroesophageal reflux symptom in patients who underwent continuous ambulatory peritoneal dialysis (CAPD) and the efficacy of proton pump inhibitor (PPI) in treating gastroesophageal reflux. Methods Fifty-eight CAPD patients with good clinical and complete dialyzed eondition,who was admitted to the hospital between Jan. 2008 and July 2008, were inquired about their gastroesophageal reflux symptoms using reflux disease questionnaire (RDQ). The patients who had RDQ≥6 and <12 were received esomeprazole 20 mg daily, while those with RDQ≥12 were received esomeparzole 20 mg twice daily. RDQ score was reevaluated 4 weeks after treatment.Results The common symptom was regurgitation (64.70%), followed by acid reflux (52.9 %), non-cardic chest pain (47.1. %) and heart burn (17. 6%). After 4-week treatment, the RDQ was significantly decreased (P< 0. 05). But there was no difference in outcome of treatment between patients with RDQ≥ 12 and RDQ< 12 (P=0. 059). Conclusion The gastroesophageal reflux symptom in CAPD patients can be relieved by PPI administration, but a larger clinical trial is needed to evaluate the course and efficacy of treatment.
