Expression and clinical significance of Topo Ⅱα , COX-2 in breast cancer tissues

VernacularTitle:乳腺癌组织中拓扑异构酶Ⅱα和环氧合酶-2的表达及其临床意义
Author: Gang XU ; Zhongfu SHAO ; Xiaofang DENG ; Lizhen HE
Publication Type:Journal Article
Keywords: Breast neoplasms; DNA Topoisomerase Ⅱα; Cyclooxygenase 2
From: Cancer Research and Clinic 2011;23(2):100-102
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of Topo Ⅱα and COX-2 in breast cancer tissues and investigate their correlations to clinicopathologic feature of breast cancer. MethodsThe expression of Topo Ⅱα and COX-2 in 50 specimens of breast cancer and their normal tissues were detected by immunohistochemistry. Their correlation to clinicopathologic features of breast cancer were analyzed.ResultsThe positive rates of Topo Ⅱα were 64 % (32/50) and 22 % (11/50) and COX-2 were 68 % (34/50) , 14 %(7/50) in breast cancer and normal tissue (P＜0.05). The expression of Topo Ⅱα was correlated to degree of differentiation (P ＜0.05), not correlated to patient age, tumor size, clinical stage and lymph node metastasis(P ＞0.05). The expression of COX-2 was correlated to tumor size, degree of differentiation, clinical stage and lymph node metastasis (P ＜0.05), not correlated to patient age (P ＞0.05). Conclusion Topo Ⅱα and COX-2 expression can be used as an indicator for predicting the differentiation, infiltration and metastasis characteristics of breast cancer.