Role of TPSA, F/T and PSAD in diagnosis of prostate cancer
10.3760/cma.j.issn.1006-9801.2011.02.013
- VernacularTitle:TPSA、F/T及PSAD在前列腺癌诊断中的意义
- Author:
Tao JIANG
;
Liming LI
;
Guibin LIU
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Prostate specific antigen;
Prostate hyperplasia;
Diagnosis
- From:
Cancer Research and Clinic
2011;23(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of serum TPSA, the ratio of free PSA(FPSA)and TPSA(F/T) and PSAD in prostate cancer(PCa).Methods The serum TPSA and PSAD levels and the ratio of F/T of 467 patients with BPH,116 patients with PCa and 50 healthy men as normal control were determined, analyzed and compared. Results Serum TPSA of PCa (53.26±33.10) were significantly higher than that of BPH (8.12±9.70) (P <0.01), and normal control (1.51 ±1.17) (P <0.01); Serum PSAD of PCa[(1.59±1.46) ng·ml-1·cm-3] were significantly higher than that of BPH [(0.14±0.17) ng·ml-1·cm-3] (P <0.01),and normal control [(0.08±0.07) ng·ml-1·cm-3] (P <0.01); F/T of PCa (0.22±0.16) was significantly lower than that of BPH (0.27±0.15) and normal control (0.36±0.14) (P <0.01). When TPSA was limited specificity at 4 ~10 ng/ml, F/T of PCa (0.18±0.13) were significantly lower than that of BPH (0.27±0.14), (P <0.05), PSAD of Pca [(0.21 ±0.07) ng· ml -1· cm -3] were significantly higher than that of BPH [(0.11 ±0.06) ng· ml-1· cm-3], (P <0.001). When F/T was 0.16, PSAD used 0.15 as the critical value, the sensitivity, specificity of diagnostic value and positive prediction value were 81.6 %, 78.2 %, 96.1% and 53.8 %, 76.9 %, 97.9 %, respectively;And the diagnostic efficiency was the highest. ConclusionF/T and PSAD have valuable role as the diagnose marker of PCa. When PSA level between 4 ng/ml and 10 ng/ml, F/T ratio and PSAD are of significant value to differentiate PCa from BPH patients.