Research development on drug resistance of taxol and β tubulin Ⅲ
10.3760/cma.j.issn.1006-9801.2011.02.025
- VernacularTitle:紫杉醇耐药与β微管蛋白Ⅲ研究进展
- Author:
Quanliang YANG
;
Huawei JIANG
- Publication Type:Journal Article
- Keywords:
Tubulin;
Taxol;
Drug resistance,neoplasms
- From:
Cancer Research and Clinic
2011;23(2):137-139
- CountryChina
- Language:Chinese
-
Abstract:
The taxol s effect of inducing apoptosis is mainly related to its ability to promote tubulin polymerization and prevent tubulin chain depolarization. Drug resistance is the main restriction factor for clinical usage of taxol. Some basic and clinical studies support that poor response to taxol and poor prognosis are related to overexpression of β tubulin Ⅲ.
