Hydrochlorothiazide-induced phototoxic reaction.
- Author:
Jin Soon KANG
;
Tae Heung KIM
;
Ki Beom PARK
- Publication Type:Original Article
- Keywords:
Hydrochlorthiazide;
Phototoxic reaction;
Chronic exposure Hydrochlorthiazide
- MeSH:
Cataract;
Humans;
Hyperpigmentation;
Labetalol;
Male;
Middle Aged;
Skin
- From:Korean Journal of Dermatology
1992;30(4):529-534
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 49-year-old male had erythematous to rusky red papules, indurated plaques and lichenified patches with hyperpigmentation on sun-exposed areas for 6 years. Phototest revealed the decreased rninimal erythemal dose to UVA(10J/cm. Photopatch test with 5% Trandate ointment, 5% hydrochlorthiazide ointment and vaselin. as a control were all negative. Two weeks after cessation of Trandate, an oral challenge of hydrochlorthiazide followed by phototest was perfrirmed resulting in exacerbation of skin lesions and photosensitivity with a decreased MED to UVA(10J/cm) again. After the cesation of Trandate containing hydrochlorthiazide, the skin lesions were improved with complete loss of photosensitivity. But, improvement of the infiltrated or licheified plaques were delayed. Presenile cataract previously noted in the patient seemed to be related to his longstanding intake of hydrochlorthiazide.
