Effects of movement on hippocampus β-amyloid protein and amyloid precursor protein in senescence-accelerated/prone mice
10.3760/cma.j.issn.0254-1424.2011.01.002
- VernacularTitle:运动对快速老化小鼠海马β-淀粉样蛋白及淀粉样蛋白前体蛋白的影响
- Author:
Bingjie WU
;
Jianyong JIANG
;
Yonghong SUN
;
Wei YUE
;
Yumiao ZHANG
;
Min LIU
;
Ping GU
;
Mingwei WANG
- Publication Type:Journal Article
- Keywords:
Movement;
Senescence;
β-Amyloid protein;
Amyloid precursor protein;
Alzheimer's disease
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2011;33(1):2-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of movement on hippocampal β-amyloid protein ( Aβ ) and amyloid precursor protein (APP) in senescence-accelerated and senescence-prone (SAMP8) mice, and the mechanism by which movement improves learning and memory in mice with a model of Alzheimer's disease. Methods Forty 3-month-old SAMP8 mice were divided randomly into a movement group and a control group. The movement group was trained with a running wheel 10 min daily, 5 days a week in the first month, and 20 min daily in the second month. Morphological changes in the hippocampus were observed under the microscope after HE staining. The expression of Aβ in the hippocampus was detected by immumohistochemical methods and APP mRNA expression was detected by RT-PCR two months later. Results HE staining showed neuron degeneration and death, chromatin condensation and vacuolar degeneration in the hippocampus of the 5-mouth-old SAMP8 mice of the control group. The movement group showed less neuron degeneration and death, and the morphology of most cells was normal The expression of Aβ in the hippocampus of the 5-month-old SAMP8 mice in the movement group was significantly lower than that in the control group. APP mRNA expression levels in the movement group were also significantly lower.Conclusions Movement can delay neuron degeneration and down-regulate Aβ and APP mRNA expression levels in the hippocampus of SAMP8 mice. It may be an important mechanism by which movement improves learning and memory in mice with a model of Alzheimer's disease.
