Part II: Design, synthesis and antitumor action of C3/C3 bisfluoroquinolones linked-cross 2, 5-1, 3, 4oxadiazole.
- Author:
Guoqiang HU
;
Yong YANG
;
Lei YI
;
Xin WANG
;
Zhiqiang ZHANG
;
Songqiang XIE
;
Wenlong HUANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(8):1012-6
- CountryChina
- Language:English
-
Abstract:
To develop a new small molecular probe for discovering an antitumor lead compound from the replacement of carboxylic group of two molecular antibacterial fluoroquinolones with a heterocyclic ring, a series of the C3/C3 bis-fluoroquinolones tethered with an 1, 3, 4-oxadiazole ring were synthesized as their respective HCl salts, and their structures were characterized by elemental analysis and spectral data. The in vitro antitumor activity against L1210, CHO and HL60 cell lines was also evaluated via the respective IC50 values by methylthiazole trazolium (MTT) assay.
