Effect of ZL-004 on raising leukocyte count
- Author:
Haiyan SUN
;
Chungang LI
;
Lin XIAO
;
Guoping WANG
;
Quanhai LIU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(6):797-800
- CountryChina
- Language:Chinese
-
Abstract:
This study is to investigate the effect of ZL-004 on normal mouse and mice with leukopenia induced by chemotherapeutic agents. 5-Fluorouracil were administered intraperitoneally to mice to develop leucopenia, and the mice were treated with ZL-004. The number of peripheral leukocytes and the percentage of granulocyte in total WBC were examined. The results are that ZL-004 markedly raise peripheral blood leukocytes in the normal mice and the mice model of leukopenia. So, ZL-004 could protect mice against 5-fluorouracil damage and raise peripheral blood leukocyte. Features of bone marrow smears is myeloproliferative hyperactivity in the mice, particularly the matured granulocytic series were observed. The mechanism of ZL-004 is to act on the mouse bone marrow causing proliferation and differentiation.
