Synthesis and activity of some new histone deacetylases inhibitors
- Author:
Yonghao CHENG
;
Yanshen GUO
;
Haizhu HAN
;
Nan WANG
;
Guohong ZHANG
;
Zongru GUO
;
Song WU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(6):735-41
- CountryChina
- Language:Chinese
-
Abstract:
To explore novel histone deacetylase (HDAC) inhibitors with anti-tumor activity, twelve target compounds were synthesized, and their structures were confirmed by 1H NMR, MS and elemental analyses. Evaluation results in vitro showed that compound Ia exhibited potent inhibition against HDAC and is worth for further investigation. And compounds IIa, IIb, IIIa-IIIi possessed moderate HDAC inhibitory activity.
