Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation.
- Author:
Jiaming LI
;
Yonghai ZHAO
;
Guochen ZHONG
;
Zijiang LONG
;
Peng ZHOU
;
Ming YUAN
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(3):305-10
- CountryChina
- Language:Chinese
-
Abstract:
Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, 1H NMR, 13C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.
