Study of a novel compound 2460A with activities produced by fungus.
- Author:
Xiaoqiang QI
;
Fengchang ZHU
;
Yang ZHANG
;
Lianhong GUO
;
Rong JIANG
;
Qiyang HE
;
Yuan LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(2):165-9
- CountryChina
- Language:Chinese
-
Abstract:
With IL-6R as target, a new compound 2460A was identified from fungus using HTS screening model. The taxonomics of the produced strain was confirmed to be Trichoderma hazianum rifai after sequencing analysis of rDNA-ITS (internal transcribed spacer). Results showed that this compound has a binding activity on IL-6R competed with IL-6, thus it is a new ligand of IL-6R originating from microbe. With MTT assay, the anti-tumor activities of 2460A were demonstrated on CM126 and HT-29 cell lines separately, the IC50 are 2.17 x 10(-5) mol x L(-1) and 1.8 x 10(-5) mol x L(-1) respectively. The compound affected lightly the HT-29 cell cycle at S phase. Studies for the anti-tumor activity of 2460A in vivo are in progress in our lab.
