The role of ADME evaluation in translation research of innovative drug.
- Author:
Yao LIU
;
Lan HONG
;
Lushan YU
;
Huidi JIANG
;
Jianzhong CHEN
;
Qin MENG
;
Shuqing CHEN
;
Su ZENG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(1):19-29
- CountryChina
- Language:Chinese
-
Abstract:
New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.
