Synthesis and antiproliferative activities of novel 5'-Schiff-base group substituted psoralen derivatives.
- Author:
Chaoyue CHEN
;
Jianguo SUN
;
Zhizhen HUANG
;
Timtak KWOK
;
Kwokpui FUNG
;
Ping WU
;
Feiyan LIU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2011;46(1):64-9
- CountryChina
- Language:English
-
Abstract:
It was found that psoralen derivative could perform a Friedel-Crafts acylation smoothly with acetic anhydride to give 5'-acetylpsoralen in a 73% yield. In the presence of boron trifluoride etherate, 5'-acetylpsoralen reacted with both aromatic amines and aliphatic amine smoothly to afford 5'-Schiff-base group substituted psoralen derivatives in 72%-92% yields. The novel synthetic method has the advantages of cheap materials, mild reaction conditions, good yields and high regioselectivity in the Friedel-Crafts acylation. Cell viability assay by MTT demonstrates that some of the psoralen derivatives 6 have antiproliferative activities.