Construction and application of pharmacophore model of benzoylurea derivatives as beta-tubulin inhibitors.
- Author:
Limei GAO
;
Shenghua ZHANG
;
Hong YI
;
Jiandong JIANG
;
Danqing SONG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(4):462-6
- CountryChina
- Language:Chinese
-
Abstract:
Ten pharmacophore models of beta-tubulin inhibitors were established from the training set of seventeen beta-tubulin inhibitors (two categories) with comformer analysis by using the Catalyst software. The optimal pharmacophore model with two hydrophobic units and two hydrogen bond acceptor units were confirmed (RMS = 0.43, Correl = 0.98, Weight = 2.06, Config = 15.97). This pharmacophore model is able to predict the activity of known beta-tubulin inhibitors and can be further used to identify structurally diverse compounds with higher activity.
