Comparison of conductivity-water content curve and visual methods for ascertaintation of the critical water content of O/W microemulsions formation.
- Author:
Dawei XIANG
;
Tiantian TANG
;
Jinfei PENG
;
Lanlin LI
;
Xiaobo SUN
;
Daxiong XIANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(8):1052-6
- CountryChina
- Language:Chinese
-
Abstract:
This study is to screen 23 blank O/W type microemulsion (ME) samples, that is 15 samples from our laboratory, and 8 samples from literature; compare the conductivity-water content curve (CWCC) method and visual method in determining the critical water content during O/W type MEs' formation, to analyze the deficiency and the feasibility of visual method and to exploxe scientific meanings of CWCC method in judging the critical water content of O/W type MEs during formation. The results show that there is a significant difference between the theoretical feasible CWCC method and visual method in determining the critical water content (P<0.001), and the results judged by conductivity is higher than that by eye-based water content. Therefore, this article firmly confirmed the shortcomings of visual method and suggested that the eye-base "critical water content" may falls into continuous ME stage during O/W MEs' formation. Further more, the CWCC method has theoretical feasibility and scientific meanings in determining the critical water content of O/W type MEs during formation.
