G3BP: a promising target for cancer therapy.
- Author:
Hao ZHANG
;
Rongguang SHAO
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(8):945-51
- CountryChina
- Language:Chinese
-
Abstract:
G3BP (Ras-GTPase-activating protein SH3 domain binding protein), a protein which binds to RasGAP SH3 domain, belongs to RNA-binding protein family, implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase, and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation, differentiation, apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology, G3BP may provide a new target for cancer therapy.
