In vitro and in vivo anti-influenza virus activity of ribavirin injection.
- Author:
Rongmei GAO
;
Xingqiong LI
;
Weiying HE
;
Jiandong JIANG
;
Yuhuan LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(3):403-7
- CountryChina
- Language:Chinese
-
Abstract:
Ribavirin is a broad-spectrum inhibitor against several unrelated DNA or RNA viruses in vitro and in vivo. In this paper the in vitro and in vivo study of anti-influenza virus activity of ribavirin (RBV) injection had been reported. The in vitro antiviral activity of ribavirin injection against influenza virus A and B was studied by CPE. The in vivo protective action of ribavirin injection against influenza A/FM/1/47(H1N1) mouse adapted strain infected mouse was studied with mouse model. The results showed ribavirin injection has strong inhibitory activity against 7 virus strains tested in vitro. Ribavirin injection could significantly increase virus infected mouse survival rate and survival days and improve lung pathogen and lung index.
