Synthesis and antidepressant activities of aryl alkanol piperidine derivatives.
- Author:
Yongyong ZHENG
;
Kai GAO
;
Zhijie WENG
;
Jianqi LI
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(3):324-9
- CountryChina
- Language:Chinese
-
Abstract:
To explore novel monoamine reuptake inhibitor with antidepressant activity, a series of substituted aryl alkanol piperidine derivatives were designed and synthesized. All of them were new compounds, and their structures were confirmed with 1H NMR and HR-MS. The results showed that compounds 4, 5 and 8 displayed strong 5-HT, NA and DA reuptake inhibiting activities in vitro. Among the tested compounds, 4, 5 and 13 exhibited potent antidepressant activities in the mice forced swimming test. Compounds 4 and 5 have potent antidepressant activities and are worth further development.
