Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents.
- Author:
Yuchen CAI
;
Yong ZOU
;
Lijian XIAN
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(3):283-8
- CountryChina
- Language:Chinese
-
Abstract:
Vascular disrupting agents (VDAs) have presented a new kind of anti-cancer drug in recent years. VDAs take advantage of the weakness of established tumor endothelial cells and their supporting structures. In contrast to anti-angiogenic therapy, which inhibits the outgrowth of new blood vessels, vascular targeting treatments selectively attack the existing tumor vasculature. Here we summarized the anti-tumor activities, mechanisms and clinical applications of small molecule VDAs.
