Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues.
- Author:
Zhisong PIAO
;
Yabing FENG
;
Lin WANG
;
Xingquan ZHANG
;
Mao LIN
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(12):1509-15
- CountryChina
- Language:Chinese
-
Abstract:
Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).
