A Case of Anti-Glomerular Basement Membrane Disease Improved by Early Plasmapheresis and Immunosuppression Therapy.
- Author:
Jee Hyun KIM
1
;
Sun Jin YOU
;
Jun Sung PARK
;
Chang Hwa LEE
;
Gheun Ho KIM
;
Chong Myung KANG
;
So Dug LIM
;
Jong Ho LEE
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Anti-glomerular basement membrane disease;
Corticosteroids;
Plasmapheresis;
Cyclophosphamide
- MeSH:
Adrenal Cortex Hormones;
Anti-Glomerular Basement Membrane Disease;
Autoimmune Diseases;
Cyclophosphamide;
Early Diagnosis;
Glomerular Basement Membrane;
Hemorrhage;
Humans;
Immunoglobulin G;
Immunosuppression;
Inflammation;
Methylprednisolone;
Plasmapheresis;
Renal Dialysis;
Renal Insufficiency
- From:Korean Journal of Nephrology
2009;28(3):243-247
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-glomerular basement membrane disease is a rare autoimmune disease characterized by rapidly progressive renal failure and/or pulmonary hemorrhage. The presence of severe crescentic glomerular inflammation with linear deposition of immunoglobulin G along the glomerular basement membrane is pathognomonic. Because renal function is rapidly and often irretrievably destroyed, many patients require hemodialysis all through their lifetime. We report a case of 33 year(s)-old man who was diagnosed as anti-glomerular basement membrane disease without pulmonary hemorrhage. The patient was treated with pulse methylprednisolone and plasmapheresis followed by oral corticosteroid and cyclophosphamide. His renal function was successfully recovered with early diagnosis and aggressive treatment.
