Synthesis and photochemical virus inactivation of novel phenothiazines.
- Author:
Hui WEN
;
Xiaofang WANG
;
Yi HUANG
;
Jingxing WANG
;
Guangzhong YANG
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(1):72-6
- CountryChina
- Language:Chinese
-
Abstract:
Virus inactivation with photochemistry is being suitable for blood or blood products, methylene blue (MB)/light treatment has been used for viral inactivation of cellular blood components. Twelve new phenothiazines derivatives were designed and synthesized, and were used to test viral inactivation and red cell damage preliminary. Results showed that compound YWW-7 has a satisfactory activity, it could be developed as a new viral inactivation agent for blood products.
