Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity.
- Author:
Xiaofang CHEN
;
Yanbin WU
;
Jie JIN
;
Ruizhen WANG
;
Chong WANG
;
Jun LIU
- Publication Type:Journal Article
- From:
Acta Pharmaceutica Sinica
2010;45(2):263-7
- CountryChina
- Language:Chinese
-
Abstract:
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
