The effect of naloxone on the electric activity of sympathetic nerve in rabbit SMAO shock
- VernacularTitle:纳洛酮对家兔肠系膜上动脉闭塞性休克交感神经放电活动的影响
- Author:
Yiling LING
- Publication Type:Journal Article
- Keywords:
Naloxone;
Electrophysiology;
Adrenergic fibers;
Shock
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
This paper shows the influence of naloxone injected into the lateral ventricle of brain on the SMAO (superior mesenteric artery occlusion) shock in rabbits as well as the electric activity of sympathetic nerve in the course of shock.This experiment in 40 rabbits proved that the electric activity of the sympathetic nerve in the naloxone group was more enhanced and the duration was much longer than the control group after loosing the occuiation. From these it is clear that the central activity of the sympathetic nerve is related to the reversal effect of naloxone on shock. However the blood pressure in the group of naloxone could be maintained at a higher level and much longer after the electric activity of the sympathetic nerve had decreased. As a result, it may be inferred that there are still other factors contributing to the blood pressure, beside the regulation by the tonicity of sympathetic nerve. The significant extension of survival time in the naloxone group fully explained that naloxone played an important role in revering SMAO shock. Therefore naloxone is valuable in clinical treatment.
