The treatment for bladder tumor with ATRA combining with interferon alpha-2a
- VernacularTitle:全反式维甲酸联合干扰素α-2a治疗膀胱癌
- Author:
Songyi NING
;
Jian TAN
;
Qiang BU
;
Hongbing LU
;
Feilun CUI
;
Hongyao LIU
;
Dongwen WANG
- Publication Type:Journal Article
- Keywords:
Bladder neoplasm;
ATRA;
IFN-α-2a;
Apoptosis
- From:
Cancer Research and Clinic
2008;20(6):369-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of all trans-retinoic acid (ATRA) combining with Interferon α-2a on bladder tumor and the possible mechanisms. Methods Fifty female Wistar rats with bladder tumor were established and separated into 4 groups randomly that are DMSO group (A), IFN-α-2a group(B), ATRA group(C) and ATRA+IFN-α-2a group(D). Then each group was treated by drugs indicated. Finally, the weight of bladder, the stage and grade of tumor, the apoptosis and proliferation index of tumor were determined to estimate the effect of ATRA+IFN-α-2a. Results The body weights in group D are the highest and the bladder weights in group D are the lowest. The stages and grades of tumor in group D were statistically decreased compared with those in the other 3 groups. Accordingly, the apoptosis of cancer cells in group D was enhanced, whereas the proliferation index in group D was decreased significandy. Conclusion The effect of ATRA combined with Interferonα-2a on the bladder tumor is better than that of monotherapy.
