HIF-1 and ovarian tumor
- VernacularTitle:缺氧诱导因子-1与卵巢肿瘤
- Author:
Feiyun JIANG
;
Guantai NI
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor-1;
Ovarian neoplasms;
Vascular endothelial growth factor A;
Therapy
- From:
Cancer Research and Clinic
2008;20(6):427-430
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-alpha-1 (Hif-lalpha) is an active-transcription nucleoprotein produced in cellular hypoxia condition, and HIF-1 can bring tissues into adaptation reaction when the tissues are in state of hypoxis. Apart from that, the factor is involved in angiogenesis of ovarian tumor, energy metabolism, invasive metabasis of the tumor and prognosis. Therefore, a new treatment of ovarian tumor may rely on the thorough study of the relationship between HIF-1 and the tumor by investigating its expression and mechanism.
