Impact of HCV-RNA levels on HIV-1 disease progression in Chinese HIV/HCV co-infected individuals
- VernacularTitle:HCV-RNA水平对HIV/HCV合并感染者HIV疾病进展影响研究
- Author:
Jing LIU
;
Yongjun JIANG
;
Min ZHANG
;
Xin CHEN
;
Zining ZHANG
;
Liping ZHOU
;
Xia FAN
;
Yanan WANG
;
Qinghai HU
;
Di DAI
;
Haibo DING
;
Hong SHANG
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus (HIV);
Hepatitis C virus(HCV);
Co-infection;
Disease progression
- From:
Chinese Journal of Microbiology and Immunology
2008;28(6):503-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of hepatitis C virus (HCV)-RNA levels on human immunodeficiency virus (HIV)-1 disease progression in Chinese HIV/HCV co-infected individuals. Methods Cross-sectional analysis was performed among 391 HIV-infected patients for assessment of HCV-IgG, HCV-RNA, HIV-RNA, CD4 cell counts and cell surface markers of immune activation, to compare the difference of viral and immune indexes between HCV-RNA high group and HCV-RNA low group, and to elucidate the association between HCV-RNA, HIV-RNA and CD4 cell counts in HIV/HCV co-infected patients. Results (1) The percentage of anti HCV-IgG positive of former plasma donor group (93%) and drug-injection group (97.5%) were significantly higher than that of sexual transmission group (20.1%). The percentage of HCV-RNA positive of drug-injection group (89.9%) was significantly higher than that of former plasma donor group (48.3%) and sexual transmission group (62.5%), P<0.01, respectively. (2) HCV-RNA levels were positively correlated to HIV-RNA levels (r=0.237,P
