Effect of the Gardenia extracts T9 on VP16 mRNA in herpes simplex virus type-1 infected mice's brains
- VernacularTitle:栀子提取物T9对单纯疱疹病毒1型感染小鼠脑内VP16mRNA的影响
- Author:
Yizhong WANG
;
Yujing SHI
;
Yang HUANG
;
Shanshan GUO
;
Jing JIANG
;
Dan SU
;
Ye ZHAO
;
Yingjie GAO
;
Xiaolan CUI
- Publication Type:Journal Article
- Keywords:
Gardenia extracts T9;
Herpes simplex virus type-1;
Viral protein 16
- From:
Chinese Journal of Microbiology and Immunology
2008;28(6):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the Gardenia extracts T9 on herpes simplex virus (HSV) viral protein 16(VP16) in HSV-1 infected mice's brains and its potential anti-viral mechanism. Methods HSV-1 infection was induced in BALB/c mice, the expression of HSV VP16 was detected by RTPCR on the 4th, 7th, 10th, 14th, and 21st day. Results The expression of VP16 mRNA decreased in both groups of large and low doses compared with virus group at the same time. Conclusion Gardenia extracts T9 can down-regulate the expression of VP16 mRNA in HSV infected mice's brains, and it may be one of its anti-HSV mechanisms.
